中国普通外科杂志 ›› 2011, Vol. 20 ›› Issue (2): 194-199.

• 文献综述 • 上一篇    下一篇

肿瘤骨转移机制研究的新进展

胡旭民1|李玉斐1|张常华2   

  1. (1.中山大学附属第二医院 脊柱外科|广东 广州 510120; 2.中山大学附属第一医院 胃肠外科|广东 广州 510080)
  • 收稿日期:2010-08-11 修回日期:2010-11-12 出版日期:2011-02-15 发布日期:2011-02-15
  • 通讯作者: 张常华 E-mail:zhchangh@mail.sysu.edu.cn
  • 作者简介:胡旭民|中山大学中山医学院博士研究生|主要从事肿瘤转移方面的研究。李玉斐并列为第一作者。
  • 基金资助:

    教育部2008年大学生创新性实验计划项目(中山大学第24号);国家自然科学基金(30700805)。

  • Received:2010-08-11 Revised:2010-11-12 Online:2011-02-15 Published:2011-02-15

摘要:

肿瘤的骨转移由非常复杂的事件链交织而成,现代“土壤与种子”学说认为,上皮性实体肿瘤在向远处转移时,首先突破血管壁,经过上皮-间质化,在血小板的包被下,受选择素和趋化因子的作用,通过解剖捷径,定植于远隔部位,继发成骨和破骨作用改变局部微环境,为新的转移创造条件。

关键词: 肿瘤转移; 骨转移; 土壤; 种子; 综述文献

中图分类号: 

  • R 738.1

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