Chinese Journal of General Surgery ›› 2021, Vol. 30 ›› Issue (3): 254-260.doi: 10.7659/j.issn.1005-6947.2021.03.002

Previous Articles     Next Articles

Association of serum ANGPTL2 with clinicopathologic features of pancreatic cancer and its diagnostic value for pancreatic cancer

QIN Wen1, CHEN Taiwen2, ZHENG Haiping3, YANG Jianyu1, ZHU Xiaodong4    

  1. (1. Department of Pathology 4. Department of Oncology, Wuming Hospital of Guangxi Medical University, Nanning 530199, China; 2. Division of Gastric and Abdominal Oncology, Guangxi Medical University Cancer Hospital, Nanning 530021, China; 3. Department of Oncology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China)
  • Received:2021-01-20 Revised:2021-02-25 Online:2021-03-25 Published:2021-04-06

Abstract: Background and Aims: The onset of pancreatic cancer is insidious and most of the patients were diagnosed at an advanced stage, thus losing the chance of radical treatment. Therefore, finding a new biomarker for the diagnosis of pancreatic cancer is of great significance. This study was conducted to investigate the association of the serum angiopoietin-like protein 2 (ANGPTL2) in pancreatic cancer patients with the clinicopathologic characteristics and its application value in diagnosis of pancreatic cancer. 
Methods: Serum ANGPTL2 levels between 125 pancreatic cancer patients and 66 healthy subjects were compared. The relations of serum ANGPTL2 level with the clinicopathologic variables and CA19-9 level as well as the risk factors for pancreatic cancer were analyzed by statistical methods. ROC curve was used to analyze the diagnostic abilities of serum ANGPTL2, serum CA19-9 and their combined detection for pancreatic cancer.
Results: The average serum level of ANGPTL2 in pancreatic cancer patients was significantly higher than that in healthy individuals (6.52 ng/mL vs. 3.78 ng/mL, P<0.05). The serum ANGPTL2 level in pancreatic cancer patients was significantly related to tumor size, histological grade, lymph node metastasis and TNM stage (all P<0.05), and irrelevant to sex, age and distant metastasis (all P>0.05). There was a significant positive correlation between serum ANGPTL2 level and CA19-9 level (r=0.772, P<0.001). Univariate and multivariate analysis showed that diabetes mellitus (P=0.016) and ANGPTL2 (P=0.014) were independent risk factors for pancreatic cancer. The AUC values of serum ANGPTL2, CA19-9 and their combined detection for diagnosis of pancreatic cancer were 0.939, 0.953 and 0.966, with the specificity/positive predictive value of 92.4%/95.7%, 84.8%/91.9%, and 98.5%/96.4%.
Conclusion: Serum ANGPTL2 level is elevated in pancreatic cancer patients. The ANGPTL2 level is closely related to the clinicopathologic features. The combined detection of ANGPTL2 and CA19-9 has certain value in diagnosis of pancreatic cancer.

Key words: Pancreatic Neoplasms, Angiopoietin-like Proteins, Serologic Tests, Biomarkers, Tumor

CLC Number: 

  • R735.9
[1] HAN Shifeng, JIN Chunfeng, ZHU Lei. Clinical value of prognostic index in postoperative evaluation of patients with resectable pancreatic ductal adenocarcinoma [J]. Chinese Journal of General Surgery, 2021, 30(3): 247-253.
[2] . Expression of NIMA-related kinase 2 in pancreatic cancer and its clinical significance [J]. Chinese Journal of General Surgery, 2021, 30(3): 269-275.
[3] LI Mingxu, ZHONG Chengcheng, ZHANG Gongming, HU Wei, , WANG Zhong, . Expression of DEP domain protein 1B in pancreatic cancer and its clinical significance [J]. Chinese Journal of General Surgery, 2021, 30(3): 261-268.
[4] ZHANG Bo, XU Tao, XU Hao, XIA Yu, ZHOU Wence, . Identification of hub genes in pancreatic adenocarcinoma and construction of a support vector machine diagnostic classifier based on bioinformatics approaches [J]. Chinese Journal of General Surgery, 2021, 30(3): 276-285..
[5] LI Weiwei, LIU Jinlong . Advances in clinical application of circulating tumor DNA in pancreatic cancer [J]. Chinese Journal of General Surgery, 2021, 30(3): 337-342.
[6] XIE Xuewen, FEI Shuke. Research progress of the role of neutrophil extracellular traps in pancreatic diseases [J]. Chinese Journal of General Surgery, 2021, 30(3): 343-348.
[7] WANG Puxiongzhi, YU Xinzhe, SHI Xiangjun, YUAN Zhou. Research progress in immunotherapy for pancreatic ductal adenocarcinoma [J]. Chinese Journal of General Surgery, 2021, 30(3): 330-336.
[8] ZHANG Fan, LI Zedong, PENG Yu, CHEN Sheng, ZHOU Jun. Construction of decision tree for diagnosis of pancreatic cancer based on serum miRNA expression data [J]. Chinese Journal of General Surgery, 2021, 30(2): 211-218.
[9] LI Liuzheng, WANG Junfeng, XU Leisheng, AO Qiang, GAO Xuechang, GONG Guocha, SHEN Weiwen, WANG Xue, FENG Jiawei. Surgical treatment of hilar cholangiocarcinoma: a report of 44 cases [J]. Chinese Journal of General Surgery, 2021, 30(2): 140-150.
[10] HUANG Zhiwei, TAN Peng, , DU Yichao, , SHI Hao, CHEN Hao, QIAN Baolin, LIU Yu, FU Wenguang, , LI Qiu. Influence of cryptotanshinone on biological behaviors of pancreatic cancer cells and the action mechanism [J]. Chinese Journal of General Surgery, 2020, 29(9): 1060-1068.
[11] ZHOU Faquan, , CHEN Shi, SUN Hongyu, TANG Lijun. Prognostic value of the systemic immune-inflammation index in patients with pancreatic cancer: a systematic review and Meta-analysis [J]. Chinese Journal of General Surgery, 2020, 29(9): 1076-1083.
[12] GUO Min, WEI Fan, SHANG Zhonghua. Meta-analysis of clinical efficacy of combined vascular resection plus reconstruction in radical resection of hilar cholangiocarcinoma [J]. Chinese Journal of General Surgery, 2020, 29(8): 924-935.
[13] GU Yaqi, ZHAO Feng, YU Hongdong, ZHOU Maoxu. Effects of enhanced recovery after surgery on postoperative recovery and nutritional status in patients undergoing pancreatoduodenectomy for pancreatic head cancer [J]. Chinese Journal of General Surgery, 2020, 29(8): 987-993.
[14] ZOU Tiantian, QIN Wei, ZHU Ying, LI Tianen, QIN Lunxiu, DONG Qiongzhu. Immune microenvironment and immunotherapy in hepatocellular carcinoma: research progress and development directions [J]. Chinese Journal of General Surgery, 2020, 29(7): 785-797.
[15] WU Xuan, TONG Gangling, CHENG Boran, YU Shaokang, JIN Feng, WANG Shubin. Expression of dual-specificity phosphatase 2 in hepatocellular carcinoma tissue and its clinical significance [J]. Chinese Journal of General Surgery, 2020, 29(7): 820-826.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. Chinese Journal of General Surgery, 2020, 29(4): 510 -514 .
[2] . [J]. Chinese Journal of General Surgery, 2020, 29(5): 630 -634 .
[3] XIAO Weixing, ZHOU Jun, GU Mengjia, XIAO Guangyuan. Application of precise hepatectomy techniques in treatment of intrahepatic stones[J]. Chinese Journal of General Surgery, 2016, 25(2): 191 -196 .
[4] . [J]. Chinese Journal of General Surgery, 2020, 29(4): 498 -503 .
[5] BAI Ning1, 2, WANG Dong2, OUYANG Xiwu2, ZHOU Ledu2, WANG Zhiming2. Inhibitory effect of matrine against hepatic ischemia-reperfusion injury in rats and its mechanism[J]. , 2018, 27(1): 81 -86 .
[6] . [J]. Chinese Journal of General Surgery, 2020, 29(4): 504 -509 .
[7] HUANG Juan, HU Yuanping, CHEN Chuang, QI Xiaowei. Some considerations regarding clinical problems in breast cancer treatment during the special period of novel coronavirus pneumonia outbreak[J]. Chinese Journal of General Surgery, 2020, 29(2): 153 -160 .
[8] LIAO Xinfang1, LI Zhengrong2, YANG Qingshui1, ZHANG Xiangcheng2, LI Zhu1, JIE Zhigang2. Role of microRNA-139-5p and its target gene Notch1 in colorectal cancer[J]. Chinese Journal of General Surgery, 0, (): 1373 -1378 .
[9] XIANG Canhong, TONG Xuan. Surgical treatment of hilar cholangiocarcinoma: progress and controversy[J]. , 2018, 27(2): 137 -142 .
[10] HUANG Gengwen, SHEN Dingcheng, HE Wen, YANG Liu, ZHOU Shuyi, YANG Jianyi, JI Lia. Laparoscopic inguinal hernia repair with enhanced recovery after surgery protocols[J]. , 2016, 25(10): 1470 -1474 .